Publications

For the most recent publications, please visit Pubmed.

2024

• X chromosome dosage drives statin-induced dysglycemia and mitochondrial dysfunction.
  Zhang P, Munier JJ, Wiese CB, Vergnes L, Link J, Abbasi F, Ronquillo E, Scheker K, Munoz A, Kuang Y, Theusch E, Liu M, Sanchez G, Oni-Orisan A, Iribarren C, McPhaul MJ, Nomura DK, Knowles JW, Krauss RM, Medina MW, Reue K. (2024) Nature Commun. Jul 2;15(1):5571.
• Gender-affirming hormone treatment and metabolic syndrome among transgender veterans.
  Hashemi L, Buljubasic AM, Budoff MJ, Copeland LA, Jackson NJ, Jasuja GK, Gornbein J, and Reue K. (2024) JAMA Netw Open. Jul 1;7(7):e2419696.
• Early-Onset Hypertension and Sex-Specific Residual Risk for Cardiovascular Disease in Type 2 Diabetes.
  Ji H, Ebinger JE, Kwan AC, Reue K, Sullivan JC, Shyy J, Cheng S. (2024) Diabetes Care. Jun 1;47(6):1028-1031. 
• Gene Regulation and Mitochondrial Activity During White and Brown Adipogenesis Are Modulated by KDM5 Histone Demethylase.
  Vergnes L, Wiese CB, Zore T, Riestenberg C, Avetisyan R, Reue K. (2024) J Endocr Soc. 8(4):bvae029.
• The BCKDK inhibitor BT2 is a chemical uncoupler that lowers mitochondrial ROS production and de novo lipogenesis.
  Acevedo A, Jones AE, Danna BT, Turner R, Montales KP, Benincá C, Reue K, Shirihai OS, Stiles L, Wallace M, Wang Y, Bertholet AM, Divakaruni AS. (2024) J Biol Chem. 300(3):105702. 
• Sex differences in prevalence and prognosis of steatotic liver disease phenotypes: biological sex matters.
  Ji H, Yeo YH, Trivedi H, Reue K, Kwan A, Cheng S. (2023) J Hepatol 80(2):e68-e69.

2023

• The role of gonadal hormones and sex chromosomes in sex-dependent effects of early nutrition on metabolic health.
  Christians JK, Reue K. (2023) Front Endocrinol (Lausanne). 14:1304050.
• The impact of chromosomal sex on cardiometabolic health and disease.
  Wiese CB, Avetisyan R, Reue K. (2023) Trends Endocrinol Metab 34:652–665.
• Feeding neurons integrate metabolic and reproductive states in mice.
  Massa MG, Scott RL, Cara AL, Cortes LR, Sandoval NP, Park JW, Ali S, Velez LM, Tesfaye B, Reue K, van Veen JE, Seldin M, Correa SM. (2023) iScience doi.org/10.1016/j.isci.2023.107918.
• Inclusion of sex as a biological variable in biomedical sciences at the undergraduate level and beyond.
  Reue K, Arnold AP. (2023) J Womens Health 32:891–896.
• CLSTN3beta enforces adipocyte multilocularity to facilitate lipid utilization and thermogenesis.
  Qian K, Tol M, Wu J, Uchiyama L, Xiao X, Bedard Z, Weston T, Rajendran P, Vergnes L, Chen F-J, Shimanaka Y, Jami-Alahamadi Y, Cohn W, Bajar B, Lin CH, Jin B, DeNardo L, Black D, Whitelegge J, Wohlschlegel J, Reue K, Shivkumar K, Chen FJ, Young SG, Li P, Liujuan C, Tontonoz P. (2023) Nature 613:160–168.

2022

• Proteome-wide systems genetics analysis identifies UFMylation as a regulator of muscle function.
  Molendijk J, Blazev R, Mills RJ, Ng YK, Watt K, Gregorevic P, Crouch PJ, Lisowski, Reue K, Lusis AJ, Hudson JE, James DE, Seldin MM, Parker BL. (2022) Elife 11:e82951.
• Ciliary neurotrophic factor mediated neuroprotection involves profound alteration of retinal metabolism.
  Rhee DK, Wang Y, Hoeve J, Stiles L, Nguyen T, Zhang X, Vergnes L, Reue K, Shirihai O, Bok D, Yang XJ. (2022) Nat Commun 13:7037.
• Chromosomal and gonadal sex drive sex differences in lipids and hepatic gene expression in response to hypercholesterolemia and statin treatment.
  Wiese CB, Agle ZW, Zhang P, Reue K. (2022) Biol Sex Differ 13:63.
• Simultaneous monitoring of mouse grip strength and force profile distinguishes muscle physiology following surgical, pharmacologic and diet interventions.
  Munier JM, Pank, Severino A, Wang H, Zhang P, Vergnes L, Reue K. (2022) Scientific Reports 12:16428.
• Illuminating the mechanisms underlying sex differences in cardiovascular disease.
  Reue K and Wiese CB. (2022) Circ Res 130:1747–1762.
• Sex differences in heart mitochondria regulate diastolic dysfunction
  Cao Y, Vergnes L, Wang YC, Pan C, Chella Krishnan K, Moore TM, Rosa-Garrido M, Kimball TH, Zhou Z, Charugundla S, Rau CD, Seldin MM, Wang J, Wang Y, Vondriska TM, Reue K, Lusis AJ. (2022). Nat Commun 13:3850.
• Relative contributions of sex hormones, sex chromosomes, and gonads to sex differences in tissue gene regulation.
  Blencowe M, Chen X, Zhao Y, Itoh Y, McQuillen CN, Han Y, Shou BL, McClusky R, Reue K, Arnold AP, Yang X. (2022) Genome Res 32:807–824.
• Suppressing fatty acid synthase by type I interferon and chemical inhibotors as a broad spectrum anti-viral strategy against SARS-CoV-2.
  Aliyari SR, Ghaffari AA, Pernet O, Parvatiyar K, Wang Y, Gerami H, Tong AJ, Vergnes L, Takallou A, Zhang A, Wei X, Chilin LD, Wu Y, Semenkovich CF, Reue K, Smale ST, Lee B, Cheng G. (2022) Acta Pharm Sin B 12:1624–1635.
• Female and male mice have differential longterm cardiorenal outcomes following a matched degree of ischemia-reperfusion acute kidney injury.
  Soranno DE, Baker P 2nd, Kirkbride-Romeo L, Wennersten SA, Ding K, Keith B, Cavasin MA, Altmann C, Bagchi RA, Haefner KR, Montford J, Gist KM, Vergnes L, Reue K, He Z, Elajaili H, Okamura K, Nozik E, McKinsey TA, Faubel S. (2022) Sci Rep 12:643.

2021

• Sex-specific genetic regulation of adipose mitochondria and their relationship to metabolic syndrome.
  Krishnan KC, Vergnes L, Stiles L, Ma L, Mouisel E, Acin-Perez R, Pan C, Peterfy M, Reue K, Bjorkegren JLM, Laakso M, Lusis AJ. (2021) Nat Metab 3:1552–1568.
• Lipin 1 modulates mRNA splicing during fasting adaptation in liver.
  Wang H, Chan TW, Vashisht A, Drew BG, Calkin AC, Harris TE, Wohlschlegel JA, Xiao X, Reue K. (2021) JCI Insight 6:150114.
• Creatine kinase B controls futile creatine cycling in thermogenic fat.
  Rahbani JF, Roesler A, Hussain MF, Samborska B, Dykstra CB, Tsai L, Jedrychowski MP, Vergnes L, Reue K, Spiegelman BM, Kazak L. (2021) Nature 590:480–485.
• The middle lipin domain adopts a membrane-binding dimeric protein fold.
  Gu W, Gao S, Wang H, Fleming KD, Hoffmann RM, Yang JW, Patel NM, Choi YM, Burke JE, Reue K, Airola MV. (2021) Nat Commun 12:4718.
• Transcriptional regulation of N6-methyladenosine orchestrates sex-dimorphic metabolic traits.
  Salisbury DA, Casero D, Zhang Z, Wang D, Kim J, Wu X, Vergnes L, Williams K, Huertas-Velazquez, Reue K, Chen J, Sallam T. (2021) Nat Metab 3:940–953.
• Sex- and gender-based pharmacological response to drugs.
  Mauvais-Jarvis F, Berthold HK, Campesi I, Carrero JJ, Dakal S, Franconi F, Gouni-Berthold I, Heiman ML, Krautzky-Willer A, Klein SL, Murphy A, Regitz-Zagrosek V, Reue K, Rubin JB. (2021) Pharmacol Rev 73:730–762.
• Genetic regulation of liver lipids in a mouse model of insulin resistance and hepatic steatosis.
  Norheim F, Chella Krishnan K, Bjellaas T, Vergnes L, Pan C, Parks, BW, Meng Y, Lang J, Ward JA, Reue K, Mehrabian M, Gundersen TE, Peterfy M, Dalen KT, Drevon CA, Hui ST, Lusis AJ, Seldin M. (2021) Mol Syst Biol 17:e9684.

2020

• X chromosome dosage of histone demethylase KDM5C determines sex differences in adiposity.
  Link JC, Wiese CB, Chen X, Avetisyan R, Ronquillo E, Ma F, Guo X, Yao J, Allison M, Chen YI, Rotter JI, El-Sayed Moustafa JS, Small KS, Iwase S, Pellegrini M, Vergnes L, Arnold AP, Reue K. (2020) J Clin Invest 130:5688–5702.
• Induction of UCP1 and thermogenesis by a small molecule via AKAP1/PKA modulation.
  Vergnes L, Lin JY, Davies GR, Church CD, Reue K. (2020) J Biol Chem 295:15054–15069.
• Isoquinoline thiosemicarbazone displays potent anticancer activity with in vivo efficacy against aggressive leukemias.
  Sun DL, Poddar S, Pan RD, Rosser EW, Abt ER, Van Valkenburgh J, Le TM, Lok V, Hernandez SP, Song J, Li J, Turlik A, Chen X, Cheng CA, Chen W, Mona CE, Stuparu AD, Vergnes L, Reue K, Damoiseaux R, Zink JI, Czernin J, Donahue TR, Houk KN, Jung ME, Radu CG. (2020) RSC Med Chem 11:392–410.
• Isolation and functional analysis of peridroplet mitochondria from murine brown adipose tissue.
  Ngo J, Benador IY, Brownstein AJ, Vergnes L, Veliova M, Shum M, Acin-Perez R, Reue K, Shirihai OS, Liesa M. (2020) STAR Protoc 2:100243.
• A novel approach to measure mitochondrial respiration in frozen biological samples.
  Acin-Perez R, Benador IY, Petcherski A, Veliova M, Benavides GA, Lagarrigue S, Caudal A, Vergnes L, Murphy AN, Karamanlidis G, Tian R, Reue K, Wanagat J, Sacks H, Amati F, Darley-Usmar VM, Liesa M, Divakaruni AS, Stiles L, Shirihai OS. (2020) EMBO J 39:e104073.
• Estrogen receptor alpha controls metabolism in white and brown adipocytes by regulating Polg1 and mitochondrial remodeling.
  Zhou Z, Moore TM, Drew BG, Ribas V, Wanagat J, Civelek M, Segawa M, Wolf DM, Norheim F, Seldin M, Strumwasser AR, Whitney KA, Lester E, Reddish BR, Vergnes L, Reue K, Rajbhandari P, Tontonoz P, Lee J, Mahata SK, Hewitt SC, Shirihai O, Gastonbury C, Small KS, Laakso M, Jensen J, Lee S, Drevon CA, Korach KS, Lusis AF, Hevener AL. (2020) Sci Transl Med 12:eaax8096. [DOI: 10.1126/scitranslmed.aax8096]
• Crystal structure of a lipin/Pah phosphatidic acid phosphatase.
  Khayyo VI, Hoffmann RM,Wang H, Bell JA, Burke JE, Reue K, Airola MV. (2020) Nat Commun 11:1309.
• Deficiency in ZMPSTE24 and resulting farnesyl-prelamin A accumulation only modestly affect mouse adipose tissue stores.
  Heizer PJ, Yang Y, Tu Y, Kim PH, Chen NY, Hu Y, Yoshinaga Y, de Jong PJ, Vergnes L, Morales JE, LiRL, Jackson N, Reue K, Young SG, Fong LG. (2020) J Lipid Res 16:413–421.

2019

• Sex-specific metabolic functions of adipose lipocalin-2.
  Chella Krishnan K, Sabir S, Shum M, Meng Y, Acin-Perez R, Lang JM, Floyd RR, Vergnes L, Seldin MM, Fuqua BK, Jayasekera DW, Nand SK, Anum DC, Pan C, Stiles L, Peterfy M, Reue K, Liesa M, Lusis AJ. (2019) Mol Metab 30:30–47.
• Single cell analysis reveals immune cell–adipocyte crosstalk regulating the transcription of thermogenic adipocytes.
  Rajbhandari P, Arneson D, Hart SK, Ahn IS, Diamante G, Santos LC, Zaghari N, Feng AC, Thomas BJ, Vergnes L, Lee SD, Rajbhandari AK, Reue K, Smale ST, Yang X, Tontonoz P. (2019) Elife 8.pii:e49501.
• Diesel exhaust induces mitochondrial dysfunction, hyperlipidemia, and liver steatosis.
  Yin F, Gupta R, Vergnes L, Driscoll WS, Ricks J, Ramanathan G, Stewart JA, Shih DM, Faull KF, Beaven SW, Lusis AJ, Reue K, Rosenfeld ME, Araujo JA. (2019) Arterioscler Thromb Vasc Biol 39:1776–1786.
• XX sex chromosome complement promotes atherosclerosis in mice.
  AlSiraj Y, Chen X, Thatcher SE, Temel RE, Cai L, Blalock E, Katz W, Ali HM, Petriello M, Deng P, Morris A, Wang X, Lusis AJ, Arnold AP, Reue K, Thompson K, Tso P, Cassis LA. (2019) Nat Commun 10:2631.
• Stimulation of hair growth by small molecules that activate autophagy.
  Chai M, Jiang M, Vergnes L, Fu X, de Barros SC, Doan NB, Huang W, Chu J, Jiao J, Herschman H, Crooks GM, Reue K, Huang J. (2019) Cell Rep 27:3413–3421. [DOI: 10.1016/j.celrep.2019.05.070]
• Noggin depletion in adipocytes promotes obesity in mice.
  Blazquez-Medela AM, Jumabay M, Rajbhandari P, Sallam T, Guo Y, Yao J, Vergnes L, Reue K, Zhang L, Yao Y, Fogelman AM, Tontonoz P, Lusis AJ, Wu X, Bostrom KI. (2019) Mol Metab 25:50–63.
• Mammalian lipin phosphatidic acid phosphatases in lipid synthesis and beyond: metabolic and inflammatory disorders.
  Reue K, Wang H. (2019) J Lipid Res 60: 728–733.
• Gene-by-sex interactions in mitochondrial functions and cardio-metabolic traits.
  Norheim F, Hasin-Brumshtein Y, Vergnes L, Chella Krishnan K, Pan C, Seldin MM, Hui ST, Mehrabian M, Zhou Z, Gupta S, Parks BW, Walch A, Reue K, Hoffman S, Arnold AP, Lusis AJ. (2019) Cell Metab 29:932–949.e4.
• Lipin 2/3 phosphatidic acid phosphatases maintain phospholipid homeostasis to regulate chylomicron synthesis.
  Zhang P, Csaki LS, Ronquillo E, Baufeld LJ, Lin JY, Gutierrez A, Dwyer JR, Brindley DN, Fong LG, Tontonoz P, Young SG, Reue K. (2019) J Clin Invest 129: 281–295.
• PON2 deficiency leads to increased susceptibility to diet-induced obesity.
  Shih DM, Meng Y, Sallam T, Shu ML, Reue K, Tontonoz P, Fogelman AM, Lusis AJ, Reddy ST. (2019) Antioxidants 8. Pii: E19.

2018

• Sex differences in obesity, lipid metabolism, and inflammation-A role for the sex chromosomes?
  Zore T, Palafox M, Reue K. Mol Metab. (2018);15:35-44. doi: 10.1016/j.molmet.2018.04.003.
• Diet1, bile acid diarrhea, and FGF15/19: mouse model and human genetic variants.
  Lee JM, Ong JR, Vergnes L, de Aguiar Vallim TQ, Nolan J, Cantor RM, Walters JRF, Reue K. J Lipid Res. (2018). pii: jlr.M078279. doi: 10.1194/jlr.M078279.
• Deciphering the role of lipid droplets in cardiovascular disease: a report from the 2017 National Heart, Lung, and Blood Institute Workshop.
  Goldberg IJ, Reue K, Abumrad NA, Bickel PE, Cohen S, Fisher EA, Galis ZS, Granneman JG, Lewandowski ED, Murphy R, Olive M, Schaffer JE, Schwartz-Longacre L, Shulman GI, Walther TC, Chen J. (2018) Circulation 138:305–315.
• KDM4B protects against obesity and metabolic dysfunction.
  Cheng Y, Yuan Q, Vergnes L, Rong X, Youn JY, Li J, Yu Y, Liu W, Cai H, Lin JD, Tontonoz P, Hong C, Reue K, Wang CY. (2018) Proc Natl Acad Sci USA 115:E5566–E5575.
• Tip60-mediated lipin 1 acetylation and ER translocation determine triacylglycerol synthesis rate.
  Li TY, Song L, Sun Y, Li J, Yi C, Lam SM, Xu D, Zhou L, Li X, Yang Y, Zhang CS, Xie C, Huang X, Shui G, Lin SY, Reue K, Lin SC. (2018) Nat Commun 9:1916.
• A strategy for discovery of endocrine interactions with application to whole-body metabolism.
  Seldin MM, Koplev S, Rajbhandari P, Vergnes L, Rosenberg GM, Meng Y, Pan C, Phuong TMN, Gharakhanian R, Che N, Mäkinen S, Shih DM, Civelek M, Parks BW, Kim ED, Norheim F, Chella Krishnan K, Hasin-Brumshtein Y, Mehrabian M, Laakso M, Drevon CA, Koistinen HA, Tontonoz P, Reue K, Cantor RM, Björkegren JLM, Lusis AJ. (2018) Cell Metab 27:1138–1155.
• NanoSIMS analysis of intravascular lipolysis and lipid movement across capillaries and into cardiomyocytes.
  He C, Weston TA, Jung RS, Heizer P, Larsson M, Hu X, Allan CM, Tontonoz P, Reue K, Beigneux AP, Ploug M, Holme A, Kilburn M, Guagliardo P, Ford DA, Fong LG, Young SG, Jiang H. (2018) Cell Metab 27:1055–1066.
• Estrogen receptor alpha protects pancreatic beta cells from apoptosis by preserving mitochondrial function and suppressing endoplasmic reticulum stress.
  Zhou Z, Ribas V, Rajbhandari P, Drew BG, Moore TM, Fluitt AH, Reddish BR, Whitney KA, Georgia S, Vergnes L, Reue K, Liesa M, Shirihai O, van der Bliek AM, Chi NW, Mahata SK, Tiano JP, Hewitt SC, Tontonoz P, Korach KS, Mauvais-Jarvis F, Hevener AL. (2018) J Biol Chem 293:4735–4751.
• Integration of multi-omics data from mouse diversity panel highlights mitochondrial dysfunction in non-alcoholic fatty liver disease.
  Chella Krishnan K, Kurt Z, Barrere-Cain R, Sabir S, Das A, Floyd R, Vergnes L, Zhao Y, Che N, Charugundla S, Qi H, Zhou Z, Meng Y, Pan C, Seldin MM, Norheim F, Hui S, Reue K, Lusis AJ, Yang X. (2018) Cell Syst 6:103–115.
• IL-10 signaling remodels adipose chromatin architecture to limit thermogenesis and energy expenditure.
  Rajbhandari P, Thomas BJ, Feng AC, Hong C, Wang J, Vergnes L, Sallam T, Wang B, Sandhu J, Seldin MM, Lusis AJ, Fong LG, Katz M, Lee R, Young SG, Reue K, Smale ST, Tontonoz P. (2018) Cell 172:218–233.

2017

• How lipid droplets "TAG" along: Glycerolipid synthetic enzymes and lipid storage.
  Wang H, Airola MV, Reue K. (2017) Biochim Biophys Acta. pii: S1388-1981(17)30114-2. doi: 10.1016/j.bbalip.2017.06.010. Review.
• The Genetic Basis for Sex Differences in Obesity and Lipid Metabolism.
  Link JC, Reue K. Annu Rev Nutr. (2017). doi: 10.1146/annurev-nutr-071816-064827. Review.
• A Guide for the Design of Pre-clinical Studies on Sex Differences in Metabolism.
  Mauvais-Jarvis F, Arnold AP, Reue K. (2017) Cell Metab. 25(6):1216-1230. doi: 10.1016/j.cmet.2017.04.033. Review.
• Lipin proteins and glycerolipid metabolism: Roles at the ER membrane and beyond.
  Zhang P, Reue K. (2017) Biochim Biophys Acta. pii: S0005-2736(17)30123-2. doi: 10.1016/j.bbamem.2017.04.007. Review.
• Sex differences in obesity: X chromosome dosage as a risk factor for increased food intake, adiposity and co-morbidities.
  Reue K. (2017) Physiol Behav. pii: S0031-9384(17)30005-7. doi: 10.1016/j.physbeh.2017.02.040. Review.
• Diet, gonadal sex, and sex chromosome complement influence white adipose tissue miRNA expression.
  Link JC, Hasin-Brumshtein Y, Cantor RM, Chen X, Arnold AP, Lusis AJ, Reue K. (2017) BMC Genomics. 18(1):89. doi: 10.1186/s12864-017-3484-1.
• Metformin induces distinct bioenergetic and metabolic profiles in sensitive versus resistant high grade serous ovarian cancer and normal fallopian tube secretory epithelial cells.
  Hodeib M, Ogrodzinski MP, Vergnes L, Reue K, Karlan BY, Lunt SY, Aspuria PP. (2017) Oncotarget 9:4044¬4060.
• Glucose inhibits cardiac muscle maturation through nucleotide biosynthesis.
  Nakano H, Minami I, Braas D, Pappoe H, Wu X, Sagadevan A, Vergnes L, Fu K, Morselli M, Dunham C, Ding X, Stieg AZ, Gimzewski JK, Pellegrini M, Clark PM, Reue K, Lusis AJ, Ribalet B, Kurdistani SK, Christofk H, Nakatsuji N, Nakano A. (2017) Elife 6. Pii:e29330
• Autoantibodies against GPIHBP1 as a cause of hypertriglyceridemia.
  Beigneux AP, Miyashita K, Ploug M, Blom DJ, Ai M, Linton MF, Khovidhunkit W, Dufour R, Garg A, McMahon MA, Pullinger CR, Sandoval NP, Hu X, Allan CM, Larsson M, Machida T, Murakami M, Reue K, Tontonoz P, Goldberg IJ, Moulin P, Charrière S, Fong LG, Nakajima K, Young SG. (2017) N Engl J Med 376:1647-1658.
• Sex hormones and sex chromosomes cause sex differences in the development of cardiovascular diseases.
  Arnold AP, Cassis LA, Eghbali M, Reue K, Sandberg K. (2017) Arterioscler Thromb Vasc Biol 37:746-756.
• RNA-binding protein PSPC1 promotes the differentiation-dependent nuclear export of adipocyte RNAs.
  Wang J, Rajbhandari P, Damianov A, Han A, Sallam T, Waki H, Villanueva CJ, Lee SD, Nielsen R, Mandrup S, Reue K, Young SG, Whitelegge J, Saez E, Black DL, Tontonoz P. (2017) J Clin Invest 127:987-1004.