The Reue Lab's primary research goal is to identify genes, pathways, and the role of biological sex in the development of cardiometabolic disease. Using genetic manipulation in mouse models, our findings have revealed independent roles for gonadal hormones and genetic sex (XX vs. XY chromosomes) in white and brown fat development and function, atherosclerosis, dietary lipid absorption, fatty liver, physiological response to exercise, mitochondrial function, and adverse drug effects. We are investigating the molecular mechanisms by which sex chromosomes influence these traits, including histone modifications, DNA methylation, and RNA expression.